This is the Mary Stegmaier mansion, on South Franklin Street.
If memory serves, the Red Cross used to be here, and WKRZ AM and FM were in a structure on the same property, to the left and rear of this photo.
It was up for sale, for $450,000 when I took this photograph, and below is the entry from the real estate agent web site.
Three-story historic mansion built in 1907 by the owners of the Stegmaier Brewing Company. This building is in excellent condition designed with stained glass windows and a solarium of stained glass. It is located in the historic district of Wilkes-Barre adjacent to Wilkes University. There is a large 2-car garage to the rear and off-street parking for 15 cars. It is ideal for office or residential use.
The property is located in the downtown Wilkes-Barre business district.